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. 2014 Oct:98:84-90.
doi: 10.1016/j.fitote.2014.07.005. Epub 2014 Jul 10.

Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity

Liuqiang Zhang  1 , Tiantian Zhu  1 , Fei Qian  1 , Jinwen Xu  2 , Gaawe Dorje  3 , Zhili Zhao  1 , Fujiang Guo  4 , Yiming Li  5
Affiliations

Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth. and their anti-inflammatory activity

Liuqiang Zhang et al. Fitoterapia. 2014 Oct.

Abstract

Scrodentosides A-E (1-5), five new acylated iridoid glycosides, together with 19 known ones, were isolated from the whole plant of Scrophularia dentata Royle ex Benth. The structures of these isolated glycosides were elucidated by spectroscopic methods. Bioassay showed that compounds 7 and 11 had significant inhibitory effect against NF-κB activation with IC50 value of 43.7 μM and 1.02 μM respectively.

Keywords: 8-O-acetylharpagide (PubChem CID: 160879); Ajugol(PubChem CID: 6452750); Ajugoside (PubChem CID: 179611); Anti-inflammation; Cis-harpagoside (PubChem CID: 13889700); Geniposidic acid(PubChem CID: 443354); Iridoid glycosides; NF-κB; Scrophularia dentata; Scropolioside D (PubChem CID: 6918700); Trans-harpagoside (PubChem CID: 5281542); harpagide (PubChem CID: 93045).

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