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Review
. 2014 Aug 15;24(16):3683-9.
doi: 10.1016/j.bmcl.2014.06.053. Epub 2014 Jun 26.

Confronting the challenges of discovery of novel antibacterial agents

Sheo B Singh  1
Affiliations
Free article
Review

Confronting the challenges of discovery of novel antibacterial agents

Sheo B Singh. Bioorg Med Chem Lett. .
Free article

Abstract

Bacterial resistance is inevitable and is a growing concern. It can be addressed only by discovery and development of new agents. However the discovery and development of new antibacterial agents are at an all time low. This article broadly examines the historical as well as current status of antibacterial discovery and provides some perspective as how to address some of the challenges.

Keywords: Antibacterial; Antimicrobial; Discovery strategy; Phenotypic screening; Topoisomerase II.

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