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Review
. 2014 Aug;18(3):561-74.
doi: 10.1016/j.cld.2014.05.004.

Acute-on-chronic liver failure

Sumeet K Asrani  1 , Jacqueline G O'Leary  2
Affiliations
Review

Acute-on-chronic liver failure

Sumeet K Asrani et al. Clin Liver Dis. 2014 Aug.

Abstract

The Model for End-Stage Liver Disease (MELD) has been the single best predictor of outcome of the progression of cirrhosis. Acute-on-chronic liver failure (ACLF) has been proposed as an alternative path in the natural history of cirrhosis. ACLF occurs in patients with chronic liver disease and is characterized by a precipitating event, resulting in acute deterioration in liver function, multiorgan system failure, and high short-term mortality. In this review, the natural course of patients with ACLF, especially as it relates to management of cirrhotic patients on the transplant waiting list, and its impact on liver transplantation outcomes are defined.

Keywords: Acute liver failure; Acute-on-chronic liver failure; Cirrhosis; Liver transplantation; Organ failure.

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References

    1. Asrani SK, Larson JJ, Yawn B, et al. Underestimation of liver-related mortality in the United States. Gastroenterology. 2013;145:375–82. e1–2. - PMC - PubMed
    1. Manos MM, Leyden WA, Murphy RC, et al. Limitations of conventionally derived chronic liver disease mortality rates: Results of a comprehensive assessment. Hepatology. 2008;47:1150–7. - PubMed
    1. Kim WR, Brown RS, Jr, Terrault NA, et al. Burden of liver disease in the United States: summary of a workshop. Hepatology. 2002;36:227–42. - PubMed
    1. Olson JC, Wendon JA, Kramer DJ, et al. Intensive care of the patient with cirrhosis. Hepatology. 2011;54:1864–1872. - PubMed
    1. Jalan R, Gines P, Olson JC, et al. Acute-on Chronic Liver Failure. J Hepatol. 2012 - PubMed

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