Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989;98(3):430-1.
doi: 10.1007/BF00451700.

Regional homovanillic acid levels and oral movements in rats following chronic haloperidol treatment

S A Kolenik 3rd  1 , F J Hoffman Jr, M B Bowers Jr
Affiliations

Regional homovanillic acid levels and oral movements in rats following chronic haloperidol treatment

S A Kolenik 3rd et al. Psychopharmacology (Berl). 1989.

Abstract

Rats with more severe orofacial movements after 51 days of haloperidol administration showed lower levels of the dopamine metabolite homovanillic acid (HVA) in the caudate compared to animals who did not develop significant mouth movements. This effect was not observed in other brain regions sampled. This finding is consistent with the hypothesis that dopaminergic receptor supersensitivity in neostriatal structures plays some role in the development of orofacial movements in rats, in association with chronic neuroleptic administration.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. J Pharm Pharmacol. 1979 Aug;31(8):558-9 - PubMed
    1. Psychopharmacology (Berl). 1988;94(3):421-7 - PubMed
    1. Neuropharmacology. 1974 Nov;13(10-11):927-40 - PubMed
    1. J Clin Psychopharmacol. 1987 Feb;7(1):57-9 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1980 Jun;312(2):151-9 - PubMed

LinkOut - more resources