Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2011 Jun;1(1):6-9.
doi: 10.1038/kisup.2011.6.

The dysfunctional endothelium in CKD and in cardiovascular disease: mapping the origin(s) of cardiovascular problems in CKD and of kidney disease in cardiovascular conditions for a research agenda

Danilo Fliser  1 , Andrzej Wiecek  2 , Gultekin Suleymanlar  3 , Alberto Ortiz  4 , Ziad Massy  5 , Bengt Lindholm  6 , Alberto Martinez-Castelao  7 , Rajiv Agarwal  8 , Kitty J Jager  9 , Friedo W Dekker  10 , Peter J Blankestijn  11 , David Goldsmith  12 , Adrian Covic  13 , Gerard London  14 , Carmine Zoccali  15 ; for EUropean REnal and CArdiovascular Medicine working group of the European Renal Association–European Dialysis and Transplant Association (ERA–EDTA)
Affiliations
Review

The dysfunctional endothelium in CKD and in cardiovascular disease: mapping the origin(s) of cardiovascular problems in CKD and of kidney disease in cardiovascular conditions for a research agenda

Danilo Fliser et al. Kidney Int Suppl (2011). 2011 Jun.

Abstract

Endothelial dysfunction resulting in disintegration of vascular structure and function is a key element in the progression of chronic kidney disease (CKD). Many risk factors-traditional and non-traditional-are thought to have a role in the progression and development of cardiovascular disease (CVD) in patients with CKD. However, many risk factors await definitive confirmation of their clinical relevance obtained from intervention trials. Moreover, the investigation of the relative contribution of these factors to the twin-risk problem of CVD and progression in patients with CKD is one of the most important future challenges for nephrologists.

Keywords: biomarkers; cardiovascular disease; chronic kidney disease; endothelium.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Some open questions on the role of endothelium in the cardio-renal connection.
See this image and copyright information in PMC

References

    1. Aird WC. Phenotypic heterogeneity of the endothelium. I. Structure, function, and mechanisms. Circ Res. 2007;100:158–173. - PubMed
    1. Aird WC. Phenotypic heterogeneity of the endothelium. II. Representative vascular beds. Circ Res. 2007;100:173–190. - PubMed
    1. Tang EH, Vanhoutte PM. Endothelial dysfunction: a strategic target in the treatment of hypertension. Pflugers Arch. 2010;459:995–1004. - PubMed
    1. Deanfield J, Donald A, Ferri C, et al. Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens. 2005;23:7–17. - PubMed
    1. Brunner H, Cockcroft JR, Deanfield J, et al. Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases: a statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens. 2005;23:233–246. - PubMed

LinkOut - more resources