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Review
. 2014:2014:740926.
doi: 10.1155/2014/740926. Epub 2014 Jun 12.

Chondrogenic differentiation of human adipose-derived stem cells: a new path in articular cartilage defect management?

Jan-Philipp Stromps  1 , Nora Emilie Paul  2 , Björn Rath  3 , Mahtab Nourbakhsh  2 , Jürgen Bernhagen  4 , Norbert Pallua  2
Affiliations
Review

Chondrogenic differentiation of human adipose-derived stem cells: a new path in articular cartilage defect management?

Jan-Philipp Stromps et al. Biomed Res Int. 2014.

Abstract

According to data published by the Centers for Disease Control and Prevention, over 6 million people undergo a variety of medical procedures for the repair of articular cartilage defects in the U.S. each year. Trauma, tumor, and age-related degeneration can cause major defects in articular cartilage, which has a poor intrinsic capacity for healing. Therefore, there is substantial interest in the development of novel cartilage tissue engineering strategies to restore articular cartilage defects to a normal or prediseased state. Special attention has been paid to the expansion of chondrocytes, which produce and maintain the cartilaginous matrix in healthy cartilage. This review summarizes the current efforts to generate chondrocytes from adipose-derived stem cells (ASCs) and provides an outlook on promising future strategies.

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Figures

Figure 1
Figure 1
Concepts of the chondrogenic differentiation of ASCs: (a) human lipoaspirate after centrifugation, (b) isolated ASCs in vitro, (c) different induction methods for chondrogenic differentiation, and (d) SOX-9 immunostaining for chondrogenic detection.
See this image and copyright information in PMC

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