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Review
. 2014 Oct:113-115:13-20.
doi: 10.1016/j.prostaglandins.2014.07.002. Epub 2014 Jul 11.

ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer

Weicang Wang  1 , Julia Zhu  1 , Fei Lyu  1 , Dipak Panigrahy  2 , Katherine W Ferrara  3 , Bruce Hammock  4 , Guodong Zhang  5
Affiliations
Review

ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer

Weicang Wang et al. Prostaglandins Other Lipid Mediat. 2014 Oct.

Abstract

Epidemiological and pre-clinical studies support the anti-tumor effects of ω-3 PUFAs; however, the results from human trials are mixed, making it difficult to provide dietary guidelines or recommendations of ω-3 PUFAs for disease prevention or treatment. Understanding the molecular mechanisms by which ω-3 PUFAs inhibit cancer could lead to better nutritional paradigms and human trials to clarify their health effects. The ω-3 PUFAs exert their biological activities mainly through the formation of bioactive lipid metabolites. Here we discuss the biology of cyclooxygenase, lipoxygenase and cytochrome P450 enzymes-derived ω-3-series lipid metabolites on angiogenesis, inflammation and cancer.

Keywords: Cyclooxygenase; Cytochrome P450; Lipoxygenase; ω-3 polyunsaturated fatty acids.

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