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. 2014 Nov-Dec;18(6):664-8.
doi: 10.1016/j.bjid.2014.05.011. Epub 2014 Jul 11.

Human immunodeficiency virus and hepatitis C virus/hepatitis B virus co-infection in Southern Brazil: clinical and epidemiological evaluation

Sonia Mara Raboni  1 , Felipe Francisco Tuon  2 , Nayara Carvalho Polido Beloto  3 , Henrique Demeneck  4 , Andre Oliveira  4 , Denis Largura  4 , Andressa Gervasoni Sagrado  4 , Bárbara Perdonsini Lima  4 , João Paulo Franzoni  4 , Maria Lucia Pedroso  5
Affiliations

Human immunodeficiency virus and hepatitis C virus/hepatitis B virus co-infection in Southern Brazil: clinical and epidemiological evaluation

Sonia Mara Raboni et al. Braz J Infect Dis. 2014 Nov-Dec.

Abstract

Hepatitis B virus, hepatitis C virus and human immunodeficiency virus share a similar transmission pathway and are often diagnosed in the same patient. These patients tend to have a faster progression of hepatic fibrosis. This cross-sectional study describes the demographic features and clinical profile of human immunodeficiency virus/hepatitis co-infected patients in Paraná, Southern Brazil. A total of 93 human immunodeficiency virus-infected patients attending a tertiary care academic hospital in Southern Brazil were included. Clinical, demographic and epidemiological data were evaluated. Hepatitis B virus and/or hepatitis C virus positive serology was found in 6.6% of patients. The anti-hepatitis C virus serum test was positive in 85% (79/93) of patients, and the infection was confirmed in 72% of the cases. Eighteen patients (19%) were human immunodeficiency virus/hepatitis B virus positive (detectable HBsAg). Among co-infected patients, there was a high frequency of drug use, and investigations for the detection of co-infection were conducted late. A low number of patients were eligible for treatment and, although the response to antiretroviral therapy was good, there was a very poor response to hepatitis therapy. Our preliminary findings indicate the need for protocols aimed at systematic investigation of hepatitis B virus and hepatitis C virus in human immunodeficiency virus-infected patients, thus allowing for early detection and treatment of co-infected patients.

Keywords: Co-infection; Hepatitis B; Hepatitis C; Human immunodeficiency virus.

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Figures

Fig. 1
Fig. 1
HIV/HCV co-infected patients: HCV genotypes frequency.
See this image and copyright information in PMC

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