Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1989 May 20;298(6684):1363-5.
doi: 10.1136/bmj.298.6684.1363.

Controlled trial of propranolol to prevent recurrent variceal bleeding in patients with non-cirrhotic portal fibrosis

C F Kiire  1
Affiliations
Clinical Trial

Controlled trial of propranolol to prevent recurrent variceal bleeding in patients with non-cirrhotic portal fibrosis

C F Kiire. BMJ. .

Abstract

Fifty patients with non-cirrhotic portal fibrosis who were admitted to hospital because of upper gastrointestinal bleeding were randomly assigned to treatment with either oral propranolol given in doses that reduced the resting pulse rate by 25% (25 patients) or with a placebo (25 patients). One year after the start of the study 20 patients in the propranolol group and five patients in the placebo group were free from recurrent gastrointestinal bleeding (p less than 0.0001). Giving continuous oral propranolol treatment is therefore effective in preventing recurrent upper gastrointestinal bleeding in patients with non-cirrhotic portal fibrosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lancet. 1972 Apr 15;1(7755):814-5 - PubMed
    1. Br J Cancer. 1977 Jan;35(1):1-39 - PubMed
    1. Lancet. 1981 Apr 25;1(8226):920-1 - PubMed
    1. Hepatology. 1982 Sep-Oct;2(5):528-31 - PubMed
    1. J R Coll Physicians Lond. 1987 Apr;21(2):107-10 - PubMed

Publication types

MeSH terms

LinkOut - more resources