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Review
. 2014 Oct;93(10-12):466-77.
doi: 10.1016/j.ejcb.2014.06.003. Epub 2014 Jun 24.

Dock-family exchange factors in cell migration and disease

Gilles Gadea  1 , Anne Blangy  2
Affiliations
Review

Dock-family exchange factors in cell migration and disease

Gilles Gadea et al. Eur J Cell Biol. 2014 Oct.

Abstract

Dock family proteins are evolutionary conserved exchange factors for the Rho GTPases Rac and Cdc42. There are 11 Dock proteins in mammals, named Dock1 (or Dock180) to Dock11 that play different cellular functions. In particular, Dock proteins regulate actin cytoskeleton, cell adhesion and migration. Not surprisingly, members of the Dock family have been involved in various pathologies, including cancer and defects in the central nervous and immune systems. This review proposes an update of the recent findings regarding the function of Dock proteins, focusing on their role in the control of cell migration and invasion and the consequences in human diseases.

Keywords: Adhesion; Amoeboid; Cancer; Cdc42; DHR2; Dock1; Dock10; Dock11; Dock180; Dock2; Dock3; Dock4; Dock5; Dock6; Dock7; Dock8; Dock9; Exchange factor; GPCR; Integrin; Migration; Osteoclast; Rac1; Rho GTPase; Synapse; Zizimin.

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