Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 May;18(3):375-8.
doi: 10.4103/0972-124X.134582.

Inflammatory myofibroblastic tumor of maxilla showing sarcomatous change in an edentulous site with a history of tooth extraction following periodontitis: A case report with discussion

K R Biniraj  1 , Mahija Janardhanan  2
Affiliations
Case Reports

Inflammatory myofibroblastic tumor of maxilla showing sarcomatous change in an edentulous site with a history of tooth extraction following periodontitis: A case report with discussion

K R Biniraj et al. J Indian Soc Periodontol. 2014 May.

Abstract

Inflammatory myofibroblastic tumor (IMT) is a rare tumor of uncertain origin with variable biological behavior ranging from reactive lesions to highly aggressive malignancy. Oral IMTs are extremely rare and only 25 cases had been reported so far. A case of IMT with sarcomatous transformation in an extraction site with a history of tooth extraction following tooth mobility of an upper left molar tooth is presented here. The tooth was extracted following a complaint of gingival swelling and mobility of tooth. Though malignant transformation in IMTs had been documented in the extra oral sites, wide search of associated literature suggests, this is the first case of oral IMT showing malignant change associated with gingiva. The case report attempts to highlight the variant possibilities of tooth mobility other than periodontitis and the importance of assessing the primary cause of such conditions.

Keywords: Inflammatory myofibroblastic tumor; malignant transformation; maxillary sinus; oral.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Intra oral presentation of the tumor at the site of extraction
Figure 2
Figure 2
Facial asymmetry with raised left orbit
Figure 3
Figure 3
Orthopantamograph showing an ill-defined radiolucent lesion in the left posterior maxilla
Figure 4
Figure 4
Computed tomography scan showing a soft tissue mass in the maxillary sinus with extension of the tumor into the nasal cavity, ethmoid sinus and orbit
Figure 5
Figure 5
Magnetic resonance imaging T1-weighted image with contrast showing a soft-tissue lesion involving the left maxilla, nasal cavity, orbit and ethmoid sinus with extension into the alveolus and infra temporal fossa
Figure 6
Figure 6
The sections from the orbital margin displaying sheets of atypical spindle cells showing large, pleomorphic nuclei with prominent nucleoli (H and E, ×40)
Figure 7
Figure 7
Fascicles of proliferating spindle cells admixed with numerous inflammatory cells
See this image and copyright information in PMC

References

    1. Coffin CM, Watterson J, Priest JR, Dehner LP. Extrapulmonary inflammatory myofibroblastic tumor (inflammatory pseudotumor). A clinicopathologic and immunohistochemical study of 84 cases. Am J Surg Pathol. 1995;19:859–72. - PubMed
    1. Shek AW, Wu PC, Samman N. Inflammatory pseudotumour of the mouth and maxilla. J Clin Pathol. 1996;49:164–7. - PMC - PubMed
    1. Binmadi NO, Packman H, Papadimitriou JC, Scheper M. Oral inflammatory myofibroblastic tumor: Case report and review of literature. Open Dent J. 2011;5:66–70. - PMC - PubMed
    1. Biselli R, Boldrini R, Ferlini C, Boglino C, Inserra A, Bosman C. Myofibroblastic tumours: Neoplasias with divergent behaviour. Ultrastructural and flow cytometric analysis. Pathol Res Pract. 1999;195:619–32. - PubMed
    1. Coffin CM, Dehner LP, Meis-Kindblom JM. Inflammatory myofibroblastic tumor, inflammatory fibrosarcoma, and related lesions: An historical review with differential diagnostic considerations. Semin Diagn Pathol. 1998;15:102–10. - PubMed

Publication types