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. 2014 Jul 15;10(7):743-9.
doi: 10.5664/jcsm.3862.

Short duration of sleep is associated with elevated high-sensitivity C-reactive protein level in Taiwanese adults: a cross-sectional study

Jui-Kun Chiang  1
Affiliations

Short duration of sleep is associated with elevated high-sensitivity C-reactive protein level in Taiwanese adults: a cross-sectional study

Jui-Kun Chiang. J Clin Sleep Med. .

Abstract

Background: Elevated plasma levels of high-sensitivity C-reactive protein (hs-CRP) have been associated with increased adverse health outcomes. The aim of this study was to investigate the association of sleep duration with risk of elevated hs-CRP levels in Taiwanese adults.

Methods: We examined the association between sleep duration and hs-CRP in 353 healthy adults recruited from the physical examination center at a regional hospital in southern Taiwan. Elevated hs-CRP was defined as a plasma level ≥ 0.20 mg/dL. Short sleep duration was defined as ≤ 5.5 h per day. Multiple logistic regression analysis was used to assess the association of short duration of sleep with elevated hs-CRP levels.

Results: In this study, short duration of sleep (odds ratio [OR] = 2.20; 95% confidence interval [CI]: 1.11-4.30), aged 70 years or older (OR = 4.58; 95% CI: 1.70-12.66), menopause (OR = 2.81; 95% CI: 1.52-5.3), higher heart rate (OR = 1.38; 95% CI: 1.10-1.75), higher body mass index (OR = 1.20; 95% CI: 1.09-1.34), higher white blood cell count (OR = 1.38; 95% CI: 1.14-1.66), and higher uric acid level (OR = 1.31; 95% CI: 1.06-1.63) were significantly associated with an increased risk of elevated hs-CRP levels.

Conclusions: In this study of healthy Taiwanese adults, short duration of sleep was significantly associated with elevated hs-CRP levels. Activation of pro-inflammatory pathways might represent a mechanism by which short sleep duration affects health.

Keywords: C-reactive protein; high-sensitivity CRP; hs-CRP; sleep duration.

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Figures

Figure 1
Figure 1. Smoothing curve of sleep duration against probability of elevated hs-CRP levels adjusted for significant covariates listed in Model 1 of Table 3.
Figure 2
Figure 2. Receiver operating characteristic curves for short duration of sleep (≤ 5.5 h/day) in predicting elevated hs-CRP levels.
The curve of the Model 3 was equal to that of the Model 2.
See this image and copyright information in PMC

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