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Review
. 2014:2014:569819.
doi: 10.1155/2014/569819. Epub 2014 Jun 12.

Monocytes as regulators of inflammation and HIV-related comorbidities during cART

Joshua J Anzinger  1 , Tiffany R Butterfield  1 , Thomas A Angelovich  2 , Suzanne M Crowe  3 , Clovis S Palmer  4
Affiliations
Review

Monocytes as regulators of inflammation and HIV-related comorbidities during cART

Joshua J Anzinger et al. J Immunol Res. 2014.

Abstract

Combined antiretroviral therapy (cART) extends the lifespan and the quality of life for HIV-infected persons but does not completely eliminate chronic immune activation and inflammation. The low level of chronic immune activation persisting during cART-treated HIV infection is associated with the development of diseases which usually occur in the elderly. Although T-cell activation has been extensively examined in the context of cART-treated HIV infection, monocyte activation is only beginning to be recognized as an important source of inflammation in this context. Here we examine markers and sources of monocyte activation during cART-treated HIV infection and discuss the role of monocytes during cardiovascular disease, HIV-associated neurocognitive disorder, and innate immune aging.

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Figures

Figure 1
Figure 1
Microbial translocation, residual HIV replication, and coinfections such as HCMV cause persistent monocyte activation and contribute to chronic inflammation in HIV+ individuals receiving antiretroviral therapy. This results in innate immune aging and may influence the development of age-related diseases. Image created by http://nice-consultants.com/.
See this image and copyright information in PMC

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