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Comment
. 2014 Jul 14;30(1):3-4.
doi: 10.1016/j.devcel.2014.06.031.

Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis

Lisa L Gallegos  1 , Joan S Brugge  2
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Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis

Lisa L Gallegos et al. Dev Cell. .
Free article

Abstract

The ability of the death ligand TRAIL to induce tumor cell apoptosis has led to the development of TRAIL-based cancer therapies. Reporting recently in Molecular Cell, Lu et al. (2014) show that the basis for differential TRAIL responses involves clustering of death receptor complexes by E-cadherin and the actin cytoskeleton.

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