Paternal nucleosomes: are they retained in developmental promoters or gene deserts?

Mitinori Saitou¹, Kazuki Kurimoto²

Affiliations

¹ Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin Yoshida, Sakyo-ku, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: saitou@anat2.med.kyoto-u.ac.jp.
² Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

PMID: 25026032
DOI: 10.1016/j.devcel.2014.06.025

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Paternal nucleosomes: are they retained in developmental promoters or gene deserts?

Mitinori Saitou et al. Dev Cell. 2014.

Free article

. 2014 Jul 14;30(1):6-8.

doi: 10.1016/j.devcel.2014.06.025.

Authors

Mitinori Saitou¹, Kazuki Kurimoto²

Affiliations

¹ Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin Yoshida, Sakyo-ku, Kyoto 606-8507, Japan; Institute for Integrated Cell-Material Sciences, Kyoto University, Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan. Electronic address: saitou@anat2.med.kyoto-u.ac.jp.
² Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan; JST, ERATO, Yoshida-Konoe-cho, Sakyo-ku, Kyoto 606-8501, Japan.

PMID: 25026032
DOI: 10.1016/j.devcel.2014.06.025

Abstract

Nucleosomes retained in spermatozoa may influence development and epigenetic inheritance. In this issue of Developmental Cell, Samans et al. (2014) and Carone et al. (2014) provide evidence for the predominant retention of sperm nucleosomes in gene deserts, necessitating a reevaluation of the prevailing notion claiming their enrichment over developmental promoters.

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Uniformity of nucleosome preservation pattern in Mammalian sperm and its connection to repetitive DNA elements.
Samans B, Yang Y, Krebs S, Sarode GV, Blum H, Reichenbach M, Wolf E, Steger K, Dansranjavin T, Schagdarsurengin U. Samans B, et al. Dev Cell. 2014 Jul 14;30(1):23-35. doi: 10.1016/j.devcel.2014.05.023. Epub 2014 Jul 3. Dev Cell. 2014. PMID: 24998597
High-resolution mapping of chromatin packaging in mouse embryonic stem cells and sperm.
Carone BR, Hung JH, Hainer SJ, Chou MT, Carone DM, Weng Z, Fazzio TG, Rando OJ. Carone BR, et al. Dev Cell. 2014 Jul 14;30(1):11-22. doi: 10.1016/j.devcel.2014.05.024. Epub 2014 Jul 3. Dev Cell. 2014. PMID: 24998598 Free PMC article.

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Paternal nucleosomes: are they retained in developmental promoters or gene deserts?

Affiliations

Paternal nucleosomes: are they retained in developmental promoters or gene deserts?

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