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Comment
. 2014 Jul 14;26(1):3-5.
doi: 10.1016/j.ccr.2014.06.024.

Sox2: masterminding the root of cancer

Wai Leong Tam  1 , Huck Hui Ng  2
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Comment

Sox2: masterminding the root of cancer

Wai Leong Tam et al. Cancer Cell. .
Free article

Abstract

The transcription factor Sox2 is a master regulator that maintains stemness in embryonic stem cells and neural stem cells. Using elegant lineage tracing strategies and genetic reporter mouse models, two studies (one of which is by Vanner and colleagues in this issue of Cancer Cell) now demonstrate that rare Sox2-expressing cells are the founding cancer stem cell population driving tumor initiation and therapy resistance.

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  • Quiescent sox2(+) cells drive hierarchical growth and relapse in sonic hedgehog subgroup medulloblastoma.
    Vanner RJ, Remke M, Gallo M, Selvadurai HJ, Coutinho F, Lee L, Kushida M, Head R, Morrissy S, Zhu X, Aviv T, Voisin V, Clarke ID, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJ, Marra MA, Malkin D, Northcott PA, Kool M, Pfister SM, Bader G, Hochedlinger K, Korshunov A, Taylor MD, Dirks PB. Vanner RJ, et al. Cancer Cell. 2014 Jul 14;26(1):33-47. doi: 10.1016/j.ccr.2014.05.005. Epub 2014 Jun 19. Cancer Cell. 2014. PMID: 24954133 Free PMC article.

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