Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure

Affiliations

¹ Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
² Department of Surgery, Pancreas and Biliary Surgery Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
³ Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
⁴ Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
⁵ Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: jain@steele.mgh.harvard.edu.

Comment

Vikash P Chauhan et al. Cancer Cell. 2014.

. 2014 Jul 14;26(1):14-5.

doi: 10.1016/j.ccr.2014.06.003.

¹ Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
² Department of Surgery, Pancreas and Biliary Surgery Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
³ Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
⁴ Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
⁵ Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: jain@steele.mgh.harvard.edu.

No abstract available

Comment in

Response to Chauhan et Al.: interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning.
DelGiorno KE, Carlson MA, Osgood R, Provenzano PP, Brockenbough JS, Thompson CB, Shepard HM, Frost GI, Potter JD, Hingorani SR. DelGiorno KE, et al. Cancer Cell. 2014 Jul 14;26(1):16-7. doi: 10.1016/j.ccr.2014.06.004. Cancer Cell. 2014. PMID: 25026210 Free PMC article. No abstract available.

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.
Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Provenzano PP, et al. Cancer Cell. 2012 Mar 20;21(3):418-29. doi: 10.1016/j.ccr.2012.01.007. Cancer Cell. 2012. PMID: 22439937 Free PMC article.

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