Response to Chauhan et Al.: interstitial pressure and vascular collapse in pancreas cancer-fluids and solids, measurement and meaning

Affiliations

¹ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
² Halozyme Therapeutics, Inc., San Diego, CA 92121, USA.
³ Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA; Centre for Public Health Research, Massey University, Wellington 6140, New Zealand.
⁴ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Medical Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address: srh@fhcrc.org.

Comment

Kathleen E DelGiorno et al. Cancer Cell. 2014.

. 2014 Jul 14;26(1):16-7.

doi: 10.1016/j.ccr.2014.06.004.

¹ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
² Halozyme Therapeutics, Inc., San Diego, CA 92121, USA.
³ Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA 98195, USA; Centre for Public Health Research, Massey University, Wellington 6140, New Zealand.
⁴ Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Division of Medical Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA. Electronic address: srh@fhcrc.org.

No abstract available

Comment on

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma.
Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Provenzano PP, et al. Cancer Cell. 2012 Mar 20;21(3):418-29. doi: 10.1016/j.ccr.2012.01.007. Cancer Cell. 2012. PMID: 22439937 Free PMC article.
Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure.
Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK. Chauhan VP, et al. Cancer Cell. 2014 Jul 14;26(1):14-5. doi: 10.1016/j.ccr.2014.06.003. Cancer Cell. 2014. PMID: 25026209 Free PMC article. No abstract available.

1. Brace RA. Progress toward resolving the controversy of positive Vs. negative interstitial fluid pressure. Circ. Res. 1981;49:281–297. - PubMed
1. Chauhan VP, Boucher Y, Ferrone CR, Roberge S, Martin JD, Stylianopoulos T, Bardeesy N, DePinho RA, Padera TP, Munn LL, Jain RK. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 2014 - PMC - PubMed
1. Jacobetz MA, Chan DS, Neesse A, Bapiro TE, Cook N, Frese KK, Feig C, Nakagawa T, Caldwell ME, Zecchini HI, et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut. 2013;62:112–120. - PMC - PubMed
1. Jain RK, Tong RT, Munn LL. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res. 2007;67:2729–2735. - PMC - PubMed
1. Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell. 2012;21:418–429. - PMC - PubMed