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Review
. 2014 Mar 18;18(2):214.
doi: 10.1186/cc13781.

Glutamine supplementation to critically ill patients?

Jan Wernerman
Review

Glutamine supplementation to critically ill patients?

Jan Wernerman. Crit Care. .
No abstract available

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Figures

Figure 1
Figure 1
Simulation of the additional mortality prediction from an out of range plasma glutamine concentration at ICU admittance. The solid line is the APACHE II predicted mortality rate if plasma glutamine concentration is in the range 400-930 μmol/l; the dotted line represents the predicted mortality rate when admittance plasma glutamine concentration is outside that range. The simulation suggests a 50 % mortality risk at APACHE 20 for admittance plasma glutamine concentrations out of range in contrast to a 50 % mortality risk at APACHE 30 for the range 400-930 μmol/h; Reproduced from [5] with permission.
Figure 2
Figure 2
Calculations of the likelihood of occurrence of three or more organ failures and of 30-day mortality rate in the REDOXS study related to whether randomized to glutamine (GLN) supplementation or not [1].
See this image and copyright information in PMC

References

    1. Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, Elke G, Berger MM, Day AG. Canadian Critical Care Trials Group. A randomized trial of glutamine and antioxidants in critically ill patients. N Engl J Med. 2013;368:1489–1497. doi: 10.1056/NEJMoa1212722. - DOI - PubMed
    1. Bollhalder L, Pfeil AM, Tomonaga Y, Schwenkglenks M. A systematic literature review and meta-analysis of randomized clinical trials of parenteral glutamine supplementation. Clin Nutr. 2013;32:213–223. doi: 10.1016/j.clnu.2012.11.003. - DOI - PubMed
    1. Novak F, Heyland DK, Avenell A, Drover JW, Su X. Glutamine supplementation in serious illness: a systematic review of the evidence. Crit Care Med. 2002;30:2022–2029. doi: 10.1097/00003246-200209000-00011. - DOI - PubMed
    1. Oudemans-van Straaten HM, Bosman RJ, Treskes M, van der Spoel HJ, Zandstra DF. Plasma glutamine depletion and patient outcome in acute ICU admissions. Intensive Care Med. 2001;27:84–90. doi: 10.1007/s001340000703. - DOI - PubMed
    1. Rodas PC, Rooyackers O, Hebert C, Norberg A, Wernerman J. Glutamine and glutathione at ICU admission in relation to outcome. Clin Sci (Lond) 2012;122:591–597. doi: 10.1042/CS20110520. - DOI - PMC - PubMed

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