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Review
. 2014 Sep;92(9):913-24.
doi: 10.1007/s00109-014-1190-x. Epub 2014 Jul 18.

Molecular and cellular basis of scleroderma

Beate Eckes  1 , Pia Moinzadeh, Gerhard Sengle, Nico Hunzelmann, Thomas Krieg
Affiliations
Review

Molecular and cellular basis of scleroderma

Beate Eckes et al. J Mol Med (Berl). 2014 Sep.

Abstract

Systemic sclerosis (scleroderma) is a chronic inflammatory disease that leads to fibrosis of the skin and involved internal organs. No efficient therapy is currently available. This review summarizes recent progress made in basic as well as clinical science and concludes with a concept that therapy targeting fibrosis in scleroderma needs to take into account the global microenvironment in the skin with its diverse cellular players interacting with a complex extracellular matrix environment and matrix-associated growth factors.

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