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Case Reports
. 2014 Oct;52(10):3822-3.
doi: 10.1128/JCM.01566-14. Epub 2014 Jul 16.

Unusual detection of an Acinetobacter class D carbapenemase gene, blaOXA-23, in a clinical Escherichia coli isolate

My-Van La  1 , Roland Jureen  2 , Raymond T P Lin  3 , Jeanette W P Teo  4
Affiliations
Case Reports

Unusual detection of an Acinetobacter class D carbapenemase gene, blaOXA-23, in a clinical Escherichia coli isolate

My-Van La et al. J Clin Microbiol. 2014 Oct.
No abstract available

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Figures

FIG 1
FIG 1
Schematic representation of the genetic organization of blaOXA-23. (A) In Acinetobacter baumannii, ISAba insertion sequence elements are typically found immediately upstream of blaOXA-23 (8, 9). (B) In the clinical Escherichia coli isolate, blaOXA-23 is flanked by two copies of Enterobacteriaceae insertion sequence IS1. The terminal left inverted repeat (IRL) of IS1 is indicated by the boldface nucleotides with gray shading. The putative −35 promoter of the IRL is underlined and may form hybrid promoters with existing −10 promoters, enabling transcription (11). The ISAba1-associated −35 and −10 promoters are underlined (10). The ATG start codon of OXA-23 is indicated by the vertical arrow (↓). Gray checked regions represent 100% identity between E. coli and A. baumannii. ATPase, gene encoding putative AAA ATPase; DEAD, gene encoding the putative DEAD (Asp-Glu-Ala-Asp) helicase.
See this image and copyright information in PMC

References

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    1. Poirel L, Potron A, Nordmann P. 2012. OXA-48-like carbapenemases: the phantom menace. J. Antimicrob. Chemother. 67:1597–1606. 10.1093/jac/dks121 - DOI - PubMed
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    1. Teo J, Ngan G, Balm M, Jureen R, Krishnan P, Lin R. 2012. Molecular characterization of NDM-1 producing Enterobacteriaceae isolates in Singapore hospitals. Western Pac. Surveil. Response J. 3:19–24. 10.5365/wpsar.year.2011.2.4.010 - DOI - PMC - PubMed
    1. Balm MN, Ngan G, Jureen R, Lin RT, Teo JW. 2013. OXA-181-producing Klebsiella pneumoniae establishing in Singapore. BMC Infect. Dis. 13:58–62. 10.1186/1471-2334-13-58 - DOI - PMC - PubMed

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