Why epistasis is important for tackling complex human disease genetics
- PMID: 25031624
- PMCID: PMC4062066
- DOI: 10.1186/gm561
Why epistasis is important for tackling complex human disease genetics
Erratum in
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Erratum to: Why epistasis is important for tackling complex human disease genetics.Genome Med. 2015 Sep 7;7(1):85. doi: 10.1186/s13073-015-0205-8. Genome Med. 2015. PMID: 26343148 Free PMC article. No abstract available.
Abstract
Epistasis has been dismissed by some as having little role in the genetic architecture of complex human disease. The authors argue that this view is the result of a misconception and explain why exploring epistasis is likely to be crucial to understanding and predicting complex disease.
References
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- Kauffman SA. The Origins of Order. Oxford: Oxford University Press; 1993.
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- Falconer DS, Mackay TFC. Introduction to Quantitative Genetics. 4. Essex, UK: Longman; 1996.
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