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. 2014 May;16(5):e6656.
doi: 10.5812/ircmj.6656. Epub 2014 May 5.

Metabolic syndrome, insulin resistance and Fatty liver in obese Iranian children

Forough Saki  1 , Zohreh Karamizadeh  2
Affiliations

Metabolic syndrome, insulin resistance and Fatty liver in obese Iranian children

Forough Saki et al. Iran Red Crescent Med J. 2014 May.

Abstract

Background: Obesity is a global epidemic and its morbidities such as metabolic syndrome, insulin resistance, and fatty liver leads to a spectrum of psycho-social and medical consequences.

Objectives: The objective of this study was to investigate the prevalence of fatty liver in obese Iranian children and its' association with metabolic syndrome and insulin resistance.

Patients and methods: 102 obese Iranian children, referred to pediatric clinics from March 2011 to March 2012, were enrolled in this cross-sectional study. All the patients were visited by a pediatric endocrinologist, a pediatric gastroenterologist and an expert radiologist in the evaluation of fatty liver grading.

Results: The grade of fatty liver was higher in older children (P = 0.001). It was also more in taller and heavier children (P = 0.000). The more the BMI was, the more the fatty liver grade was (P = 0.002). Severity of fatty liver according to liver sonography in patient had a positive relationship with waist circumference, hip circumference, serum TG, serum FBS, serum fasting insulin, serum ALT, systolic blood pressure and HOMA index and had a negative correlation with the level of alkaline phosphatase. Severity of fatty liver also had a close relationship with the presence of acanthosis nigricans and HOMA index.

Conclusions: Prevalence of fatty liver is high in our obese children. It was associated with criteria of metabolic syndrome and insulin resistance, so visceral fat may participate in the pathogenesis of the metabolic syndrome or merely serve as a marker of increased risk for the metabolic complications of obesity.

Keywords: Children; Fatty liver; Insulin Resistance; Iran; Obesity.

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References

    1. Tominaga K, Kurata JH, Chen YK, Fujimoto E, Miyagawa S, Abe I, et al. Prevalence of fatty liver in Japanese children and relationship to obesity. An epidemiological ultrasonographic survey. Dig Dis Sci. 1995;40(9):2002–9. - PubMed
    1. Mathur P, Das MK, Arora NK. Non-alcoholic fatty liver disease and childhood obesity. Indian J Pediatr. 2007;74(4):401–7. - PubMed
    1. Adibi A, Kelishadi R, Beihaghi A, Salehi H, Talaei M. Sonographic fatty liver in overweight and obese children, a cross sectional study in Isfahan. Endokrynol Pol. 2009;60(1):14–9. - PubMed
    1. Gupta R, Bhangoo A, Matthews NA, Anhalt H, Matta Y, Lamichhane B, et al. The prevalence of non-alcoholic fatty liver disease and metabolic syndrome in obese children. J Pediatr Endocrinol Metab. 2011;24(11-12):907–11. - PubMed
    1. Kaur S, Kapil U, Singh P. Pattern of chronic diseases amongst adolescent obese children in developing countries. Curr Sci. 2005;88(7):1052–6.

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