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. 2014 Sep;66(3):302-8.
doi: 10.1007/s12070-014-0710-x. Epub 2014 Feb 18.

Urinary neopterin levels in patients with thyroid cancer

Serap Soytac Inancli  1 , Sedat Caner  2 , Fevzi Balkan  2 , Abbas Ali Tam  2 , Gulnur Guler  3 , Reyhan Ersoy  2 , Bekir Cakir  2
Affiliations

Urinary neopterin levels in patients with thyroid cancer

Serap Soytac Inancli et al. Indian J Otolaryngol Head Neck Surg. 2014 Sep.

Abstract

Increased urinary neopterin concentrations have been described in many cancers. We aimed to evaluate the urinary neopterin levels in thyroid cancer. Sixty-nine patients with thyroid cancer, 76 patients with benign thyroid pathology and 33 healthy subjects were evaluated. First morning urine samples were collected from the patients and normal subjects for neopterin and creatinine measurement and stored at -80 °C until analysed. Neopterin levels were 149.3 (15.2-1,602.2) μmol/mol creatinine in the malignant group, 32 (5.2-275.6) μmol/mol creatinine in the benign group and 9.2 (2.7-78.7) μmol/mol creatinine in normal subjects (p ≤ 0.001). Urinary neopterin levels were significantly higher in patients with thyroid cancer than patients with benign thyroid pathologies and normal subjects. Also the patients with benign thyroid pathologies had a higher urinary neopterin level than the normal subjects. Malignant group was divided to two groups; patients with/without chronic thyroiditis (confirmed histologically). There were 22 (31.9 %) patients with and 47 (68.1 %) patients without chronic thyroiditis. Urinary levels of neopterin didn't differ in both groups (168.6 (21.3-716.8) μmol/mol creatinine and 135.3 (15.2-1,602.2) μmol/mol creatinine respectively; p = 0.381). Urinary neopterin levels are high in thyroid cancer patients independently from the presence of chronic thyroiditis.

Keywords: Hashimoto’s thyroiditis; Inflammation; Neopterin; Thyroid cancer.

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Figures

Fig. 1
Fig. 1
Preoperative urinary neopterin levels between malignant, benign and control group p < 0.001
Fig. 2
Fig. 2
Preoperative urinary neopterin levels in the malignant group according to tumor size r = 0.272, p = 0.024
See this image and copyright information in PMC

References

    1. Jemal A, Siegel R, Xu J, et al. Cancer statistics 2010. CA Cancer J Clin. 2010;60(5):277–300. doi: 10.3322/caac.20073. - DOI - PubMed
    1. Ito Y, Hirokawa M, Jikuzono T, Higashiyama T, Takamura Y, Miya A, Kobayashi K, Matsuzuka F, Kuma K, Miyauchi A. Extranodal tumor extension to adjacent organs predicts a worse cause-specific survival in patients with papillary thyroid carcinoma. World J Surg. 2007;31(6):1194–1201. doi: 10.1007/s00268-007-9042-2. - DOI - PubMed
    1. Gamagedara S, Gibbons S, Ma Y. Investigation of urinary pteridine levels as potential biomarkers for noninvasive diagnosis of cancer. Clin Chim Acta. 2011;412(1–2):120–128. doi: 10.1016/j.cca.2010.09.015. - DOI - PubMed
    1. Sucher R, Schroecksnadel K, Weiss G, Margreiter R, Fuchs D, Brandacher G. Neopterin, a prognostic marker in human malignancies. Cancer Lett. 2010;287(1):13–22. doi: 10.1016/j.canlet.2009.05.008. - DOI - PubMed
    1. Huber C, Batchelor JR, Fuchs D, Hausen A, Lang A, Niederwieser D, Reibnegger G, Swetly P, Troppmair J, Wachter H. Immune response associated production of neopterin. Release from macrophages primarily under the control of interferon γ. J Exp Med. 1984;160:310–316. doi: 10.1084/jem.160.1.310. - DOI - PMC - PubMed

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