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. 2014 Aug 1;16(15):3970-3.
doi: 10.1021/ol5017965. Epub 2014 Jul 17.

Palladium-catalyzed alkenylation of ketone enolates under mild conditions

Michael Grigalunas  1 , Tobias Ankner, Per-Ola Norrby, Olaf Wiest, Paul Helquist
Affiliations

Palladium-catalyzed alkenylation of ketone enolates under mild conditions

Michael Grigalunas et al. Org Lett. .

Abstract

A protocol for a mild, catalytic, intermolecular alkenylation of ketone enolates has been developed using a Pd/Q-Phos catalyst. Efficient intermolecular coupling of a variety of ketones with alkenyl bromides was achieved with a slight excess of LiHMDS and temperatures down to 0 °C.

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