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. 2014 Jun 15;7(6):1554-7.
eCollection 2014.

Investigation of granulomatous prostatitis incidence following intravesical BCG therapy

Mehmet Balasar  1 , Metin Doğan  2 , Abdulkadir Kandemir  1 , Hakan Hakki Taskapu  1 , Faruk Cicekci  3 , Hatice Toy  4 , Recai Gurbuz  1
Affiliations

Investigation of granulomatous prostatitis incidence following intravesical BCG therapy

Mehmet Balasar et al. Int J Clin Exp Med. .

Abstract

In the present manuscript, we studied the incidence of granulomatous prostatitis in the prostatectomy specimen of the patients who underwent transurethral resection of the prostate (TURP) after superficial bladder cancer treatment with intravesical Bacillus Calmette-Guerin (BCG) and were diagnosed with benign prostate hyperplasia (BPH). The clinical data and histopathological specimen records of 472 patients who underwent TUR-P due to BPH diagnosis, obtained over a period of 6 years in the urology department of Private Konya Hospital, Konya, Turkey, were studied retrospectively. The cases were divided into two groups as (Group I) who did not undergo any treatment and as (Group II) who underwent BCG treatment. The frequency and the clinical course of the cases with granulomatous prostatitis were studied histopathologically. There were in total 472 patients who underwent TUR-P. Out of the 459 patients who did not undergo BCG treatment (Group I), the histopathological specimen records of 262 (57%) was BPH, of 197 (43%) BPH + chronic prostatitis. Of the second group, 13 cases underwent intravesical BCG treatment before surgical intervention due to superficial bladder CA diagnosis. In this group 4 of the cases were diagnosed as (30%) BPH, 9 as (70%) chronic prostatitis + BPH. 6 out of the 9 chronic prostatitis cases were chronic prostatitis, 2 caseous granulomatous prostatitis, 1 non-caseous granulomatous prostatitis. Granulomatous prostatitis cases should require no specific therapy.

Conclusion: In patients with obstruction complaints following intravesical BCG treatment, granulomatous prostatitis should also be considered and treatment plans should be made accordingly.

Keywords: Granulomatous prostatitis; TUR-P; intravesical BCG immunotherapy.

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Figures

Figure 1
Figure 1
Granuloma structure with caseous necrosis in the center (arrow), ×100, H.E.
Figure 2
Figure 2
Red colored basils in Lang Hans type giant cells (arrow), ×400, EZN staining.
Figure 3
Figure 3
Granuloma necrosis without calcification in prostate stroma, ×100, H.E.
See this image and copyright information in PMC

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