Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Sep;63(9):4060-3.
doi: 10.1128/JVI.63.9.4060-4063.1989.

Site of the base change in the vaccinia virus DNA polymerase gene which confers aphidicolin resistance

F M DeFilippes  1
Affiliations

Site of the base change in the vaccinia virus DNA polymerase gene which confers aphidicolin resistance

F M DeFilippes. J Virol. 1989 Sep.

Abstract

An aphidicolin-resistant mutant of vaccinia virus has been shown to encode an altered viral DNA polymerase that is more resistant to aphidicolin. Marker transfer experiments with the DNA from the resistant virus localized the mutation site to an RsaI segment within the portion of the HindIII-E segment which has been shown to contain the viral DNA polymerase gene. Nucleotide sequence analysis of the mutant DNA showed a single GC to AT transition at position 2430, which indicates a leucine-to-methionine change at residue 645 in the protein.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Virology. 1983 Jul 30;128(2):444-57 - PubMed
    1. J Virol. 1982 Aug;43(2):673-8 - PubMed
    1. J Virol. 1984 Jan;49(1):72-7 - PubMed
    1. Virology. 1984 May;135(1):87-96 - PubMed
    1. J Virol. 1984 Nov;52(2):474-82 - PubMed

LinkOut - more resources