A study of cardiovascular miRNA biomarkers for Kawasaki disease
- PMID: 25037038
- PMCID: PMC4229439
- DOI: 10.1097/INF.0000000000000449
A study of cardiovascular miRNA biomarkers for Kawasaki disease
Abstract
We hypothesized that cardiovascular miRNAs might be diagnostic biomarkers for Kawasaki disease (KD). We identified dysregulated miRNAs in KD coronary arteries, and tested sera from KD patients and febrile controls for cardiovascular miRNAs using 2 methods. We did not identify cardiovascular miRNAs diagnostic for KD; our results may help guide future studies of potential miRNA biomarkers for KD.
References
-
- Newburger JW, Takahashi M, Gerber MA, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation. 2004;110(17):2747–2771. - PubMed
-
- Tijsen AJ, Pinto YM, Creemers EE. Circulating microRNAs as diagnostic biomarkers for cardiovascular diseases. American journal of physiology. Heart and circulatory physiology. 2012;303(9):H1085–1095. - PubMed
-
- Bourzac KM, Rounseville MP, Zarate X, et al. A high-density quantitative nuclease protection microarray platform for high throughput analysis of gene expression. J. Biotechnol. 2011;154(1):68–75. - PubMed
-
- Schmittgen TD, Livak KJ. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008;3(6):1101–1108. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical