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Review
. 2014 Aug;32(3):629-46, vii.
doi: 10.1016/j.ncl.2014.04.001. Epub 2014 Jun 6.

Inclusion body myositis

Mazen M Dimachkie  1 , Richard J Barohn  2
Affiliations
Review

Inclusion body myositis

Mazen M Dimachkie et al. Neurol Clin. 2014 Aug.

Abstract

The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of rare disorders that share many similarities. In addition to sporadic inclusion body myositis (IBM), these include dermatomyositis, polymyositis, and autoimmune necrotizing myopathy. IBM is the most common IIM after age 50 years. Muscle histopathology shows endomysial inflammatory exudates surrounding and invading nonnecrotic muscle fibers often accompanied by rimmed vacuoles and protein deposits. It is likely that IBM is has a prominent degenerative component. This article reviews the evolution of knowledge in IBM, with emphasis on recent developments in the field, and discusses ongoing clinical trials.

Keywords: Diagnosis; Idiopathic inflammatory myopathies; Inclusion body myositis; Pathology; Pathophysiology; Polymyositis; Prognosis; Treatment.

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Figures

Figure 1
Figure 1
Finger flexor weakness and severe thigh muscle atrophy in IBM.
Figure 2
Figure 2
PM: Inflammatory infiltrates invading non-necrotic fibers - Hematoxylin and eosin; IBM muscle: Muscle fibers with rimmed vacuoles - Modified Gomori trichrome
Figure 2
Figure 2
PM: Inflammatory infiltrates invading non-necrotic fibers - Hematoxylin and eosin; IBM muscle: Muscle fibers with rimmed vacuoles - Modified Gomori trichrome
See this image and copyright information in PMC

References

    1. Phillips BA, Zilko PJ, Mastaglia FL. Prevalence of sporadic inclusion body myositis in Western Australia. Muscle Nerve. 2000;23(6):970–972. - PubMed
    1. Tan JA, Roberts-Thomson PJ, Blumbergs P, et al. Incidence and prevalence of idiopathic inflammatory myopathies in South Australia: a 30-year epidemiologic study of histology-proven cases. Int J Rheum Dis. 2013 Jun;16(3):331–8. - PubMed
    1. Lindberg C, Persson LI, Bjorkander J, et al. Inclusion body myositis: clinical, morphological, physiological and laboratory findings in 18 cases. Acta Neurol Scand. 1994;89:123–131. - PubMed
    1. Wilson FC, Ytterberg SR, Sauver JL, et al. Epidemiology of sporadic inclusion body myositis and polymyositis in Olmsted County, Minnesota. J Rheumatol. 2008;35(3):445–7. - PubMed
    1. Lotz BP, Engel AG, Nishino H, et al. Inclusion body myositis. Observations in 40 patients. Brain. 1989;112(Pt 3):727–747. - PubMed

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