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. 2014 Aug 19;83(8):752-7.
doi: 10.1212/WNL.0000000000000710. Epub 2014 Jul 18.

Convulsive status epilepticus and health-related quality of life in children with epilepsy

Mark A Ferro  1 , Richard F M Chin  2 , Carol S Camfield  2 , Samuel Wiebe  2 , Simon D Levin  2 , Kathy N Speechley  2
Affiliations

Convulsive status epilepticus and health-related quality of life in children with epilepsy

Mark A Ferro et al. Neurology. .

Abstract

Objectives: The objective of this study was to examine the association between convulsive status epilepticus (CSE) and health-related quality of life (HRQL) during a 24-month follow-up in a multisite incident cohort of children with epilepsy.

Methods: Data were collected in the Health-Related Quality of Life Study in Children with Epilepsy Study from 374 families of children with newly diagnosed epilepsy. The Quality of Life in Childhood Epilepsy (QOLCE) Questionnaire was used to evaluate parent-reported child HRQL. Hierarchical linear regression was used to examine the relationship between CSE and HRQL at 24 months postepilepsy. A total of 359 families completed the 24-month assessment.

Results: Twenty-two children (6.1%) had experienced CSE during the follow-up. Children with and without CSE were similar, except a larger proportion of children with CSE had partial seizures (p < 0.001). Controlling for clinical, demographic, and family characteristics, CSE was significantly associated with poorer HRQL (β = -4.65, p = 0.031). The final model explained 47% of the variance in QOLCE scores.

Conclusions: The findings suggested that not only do children with CSE have significantly poorer HRQL compared with their non-CSE counterparts, but that this factor is independent of the effects of demographic and clinical features known to affect HRQL.

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Figures

Figure
Figure. Impact of CSE on health-related quality of life
Convulsive status epilepticus (CSE) was coded as absent or present. The error bars represent the 95% confidence intervals surrounding the Quality of Life in Childhood Epilepsy (QOLCE) Questionnaire scores controlling for the confounders described in table 2.
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