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. 2014 Sep;15(9):1140-6.
doi: 10.1016/j.sleep.2014.05.021. Epub 2014 Jun 13.

Objective sleep, a novel risk factor for alterations in kidney function: the CARDIA study

Megan E Petrov  1 , Yongin Kim  2 , Diane S Lauderdale  3 , Cora E Lewis  2 , Jared P Reis  4 , Mercedes R Carnethon  5 , Kristen L Knutson  3 , Stephen P Glasser  2
Affiliations

Objective sleep, a novel risk factor for alterations in kidney function: the CARDIA study

Megan E Petrov et al. Sleep Med. 2014 Sep.

Abstract

Objective: To determine the association between objectively measured sleep and 10-year changes in estimated glomerular filtration rate (eGFR).

Methods: From 2003 to 2005, an ancillary sleep study was conducted at the Chicago site of the Coronary Artery Risk Development in Young Adults (CARDIA) study. Community-based black and white adults (aged 32-51 years) wore a wrist actigraph for up to six nights to record sleep duration and fragmentation. Sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI). Participants without history of cardiovascular or chronic kidney diseases, proteinuria, or hypertension at the 2000-2001 CARDIA examination were followed over 10 years (n = 463). eGFR was estimated from serum creatinine (eGFRCr) at the 2000-2001, 2005-2006, and 2010-2011 CARDIA examinations, whereas cystatin-C-estimated eGFR (eGFRCys) was measured at the 2000-2001 and 2005-2006 examinations. Generalized estimating equation regression and linear models estimated the associations of each sleep parameter with changes in eGFRCr and eGFRCys, controlling for cardiovascular and renal risk.

Results: Sleep parameters were not related to 5-year change in eGFRCys. However, each 1 h decrease in sleep duration was significantly associated with a 1.5 mL/min/1.73 m2 higher eGFRCr [95% confidence interval (CI), 0.2-2.7], and each one-point increase in PSQI was significantly associated with a 0.5 mL/min/1.73 m2 higher eGFRCr (95% CI, 0.04-0.9) over 10 years.

Conclusion: In this community-based sample, shorter sleep and poorer sleep quality were related to higher kidney filtration rates over 10 years.

Keywords: Glomerular filtration rate; Kidney function; Objective sleep; Race; Sex; Sleep duration; Sleep quality.

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Conflict of interest statement

Conflicts of interest

Dr Lewis receives research funding unrelated to the submitted work from Novo Nordisk; Dr Glasser receives salary support from AMGEN to evaluate trials for treating elevated LDL-cholesterol.

Figures

Fig. 1
Fig. 1
Study design. CARDIA, Coronary Artery Risk Development in Young Adults Study; eGFRCr, glomerular filtration rate estimated from serum creatinine; eGFRCys, glomerular filtration rate estimated from cystatin C.
Fig. 2
Fig. 2
Glomerular filtration rate (means and standard deviations) estimated with serum creatinine across each clinical examination by race–sex groups. eGFR, estimated glomerular filtration rate; FU, follow-up.
See this image and copyright information in PMC

References

    1. Astor BC, Hallan SI, Miller ER, III, Yeung E, Coresh J. Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population. Am J Epidemiol. 2008;167:1226–34. - PubMed
    1. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003;108:2154–69. - PubMed
    1. Cappuccio FP, Cooper D, D’Elia L, Strazzullo P, Miller MA. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J. 2011;32:1484–92. - PubMed
    1. Mallon L, Broman JE, Hetta J. Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population. J Intern Med. 2002;251:207–16. - PubMed
    1. Matsushita K, Selvin E, Bash LD, Franceschini N, Astor BC, Coresh J. Change in estimated GFR associates with coronary heart disease and mortality. J Am Soc Nephrol. 2009;20:2617–24. - PMC - PubMed

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