Comment
doi: 10.1016/j.molcel.2014.07.002.
RNA binding of PRC2: promiscuous or well ordered?
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- PMID: 25038410
- DOI: 10.1016/j.molcel.2014.07.002
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Comment
RNA binding of PRC2: promiscuous or well ordered?
Mol Cell.
.
Free article
Abstract
The polycomb repressive complex 2 (PRC2) methylates histones for epigenetic silencing and associates with thousands of protein-coding and noncoding RNAs. How the recruitment of PRC2 to specific sites is facilitated is currently unclear. Two recent studies have deciphered the impact of RNA binding on PRC2 recruitment and activity (Cifuentes-Rojas et al., 2014; Davidovich et al., 2013).
Copyright © 2014 Elsevier Inc. All rights reserved.
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