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Randomized Controlled Trial
. 2014 Jul 19:14:53.
doi: 10.1186/1471-2490-14-53.

Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®)

Gian Maria Busetto  1 , Riccardo Giovannone, Matteo Ferro, Stefano Tricarico, Francesco Del Giudice, Deliu Victor Matei, Ottavio De Cobelli, Vincenzo Gentile, Ettore De Berardinis
Affiliations
Randomized Controlled Trial

Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®)

Gian Maria Busetto et al. BMC Urol. .

Abstract

Background: Bacterial prostatitis (BP) is a common condition accounting responsible for about 5-10% of all prostatitis cases; chronic bacterial prostatitis (CBP) classified as type II, are less common but is a condition that significantly hampers the quality of life, (QoL) because not only is it a physical condition but also a psychological distress. Commonly patients are treated with antibiotics alone, and in particular fluoroquinolones are suggested by the European Urology guidelines. This approach, although recommended, may not be enough. Thus, a multimodal approach to the prolonged antibiotic therapy may be helpful.

Methods: 210 patients affected by chronic bacterial prostatitis were enrolled in the study. All patients were positive to Meares-Stamey test and symptoms duration was > 3 months. The purpose of the study was to evaluate the efficacy of a long lasting therapy with a fluoroquinolone in association with a nutraceutical supplement (prulifloxacin 600 mg for 21 days and an association of Serenoa repens 320 mg, Lactobacillus Sporogens 200 mg, Arbutin 100 mg for 30 days). Patients were randomized in two groups (A and B) receiving respectively antibiotic alone and an association of antibiotic plus supplement.

Results: Biological recurrence at 2 months in Group A was observed in 21 patients (27.6%) and in Group B in 6 patients (7.8%). Uropathogens found at the first follow-up were for the majority Gram - (E. coli and Enterobacter spp.). A statistically significant difference was found at the time of the follow-up between Group A and B in the NIH-CPSI questionnaire score, symptoms evidence and serum PSA.

Conclusions: Broad band, short-lasting antibiotic therapy in association with a nutritional supplement (serenoa repens, lactobacillus sporogens and arbutin) show better control and recurrence rate on patients affected by chronic bacterial prostatitits in comparison with antibiotic treatment alone.

Trial registration: NCT02130713. Date of trial Registration: 30/04/2014.

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Figures

Figure 1
Figure 1
NIH-CPSI questionnaire. NIH-CPSI questionnaire score at baseline, 2nd, 4th and 6th month.
Figure 2
Figure 2
PSA. Serum PSA at baseline, 2nd, 4th and 6th month.
Figure 3
Figure 3
Symptoms. Presence of symptoms at baseline, 2nd, 4th and 6th month.
See this image and copyright information in PMC

References

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