Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Sep-Oct;90(5):957-64.
doi: 10.1111/php.12311. Epub 2014 Aug 20.

Chemical and biological mechanisms of pathogen reduction technologies

Janna M Mundt  1 , Lindsay Rouse, Jeroen Van den Bossche, Raymond P Goodrich
Affiliations
Free PMC article
Review

Chemical and biological mechanisms of pathogen reduction technologies

Janna M Mundt et al. Photochem Photobiol. 2014 Sep-Oct.
Free PMC article

Abstract

Within the last decade new technologies have been developed and implemented which employ light, often in the presence of a photosensitizer, to inactivate pathogens that reside in human blood products for the purpose of transfusion. These pathogen reduction technologies attempt to find the proper balance between pathogen kill and cell quality. Each system utilizes various chemistries that not only impact which pathogens they can inactivate and how, but also how the treatments affect the plasma and cellular proteins and to what degree. This paper aims to present the various chemical mechanisms for pathogen reduction in transfusion medicine that are currently practiced or in development.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Illustrated summary of photochemical mechanisms for Theraflex UVC, Mirasol, Intercept and Theraflex methylene blue (MB) pathogen reduction technologies.
See this image and copyright information in PMC

References

    1. Philips Electronics NV. Light sources for phototherapy. 4th edn. Roosendaal, The Netherlands: Business Line UV Health & Wellness; 2009.
    1. Sanvordeker DR, Kostenbauder HB. Mechanism for riboflavin enhancement of bilirubin photodecomposition in vitro. J. Pharm. Sci. 1974;63:404–408. - PubMed
    1. Gottlieb SL, Wolfe JT, Fox FE, DeNardo BJ, Macey WH, Bromley PG, Lessin SR, Rook AH. Treatment of cutaneous t-cell lymphoma with extracorporeal photopheresis monotherapy and in combination with recombinant interferon alfa: A 10-year experience at a single institution. J. Am. Acad. Dermatol. 1996;35:946–957. - PubMed
    1. Greinix HT, Volc-Platzer B, Rabitsch W, Gmeinhart B, Guevara-Pineda C, Klahs P, Krutmann J, Honigsmann H, Ciovica M, Knobler RM. Successful use of extracorporeal photochemotherapy in the treatment of severe acute and chronic graft-versus-host disease. Blood. 1998;92:3098–3104. - PubMed
    1. Couriel D, Hosing C, Saliba R, Shpall EJ, Andelini P, Popat U, Donato M, Champlin R. Extracorporeal photopheresis for acute and chronice graft-versus-host disease: Does it work? Biol. Blood Marrow Transplant. 2006;12:37–40. - PubMed