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. 2014 Jul 21:14:93.
doi: 10.1186/1471-2415-14-93.

Relative lens vault in subjects with angle closure

Young Kook Kim, Beong Wook Yoo, Hee Chan Kim, Tin Aung, Ki Ho Park  1
Affiliations

Relative lens vault in subjects with angle closure

Young Kook Kim et al. BMC Ophthalmol. .

Abstract

Background: The purpose of this study was to investigate the association of a novel biometric parameter, relative lens vault (LV), with primary angle-closure (PAC) and primary angle-closure glaucoma (PACG).

Methods: We evaluated 101 subjects with PAC (G) and 101 normal subjects that were age- and gender-matched. Based on anterior-segment optical coherence tomography scans, and using customized software, the anterior vault (AV) and LV were measured. They were defined as the maximum distances between the horizontal line connecting the two scleral spurs and the posterior corneal surface and anterior lens surface, respectively. The relative LV was calculated by dividing the LV by the AV.

Results: Significant differences between PAC (G) eyes and normal eyes were found in the LV (1.06 ± 0.41 vs. 0.36 ± 0.37 mm, P < 0.001), relative LV (0.34 ± 0.23 vs. 0.11 ± 0.25, P < 0.001), and axial length (22.96 ± 0.94 vs. 24.02 ± 1.33 mm, P < 0.001). However, the two groups' values of the AV relative to those of axial length were quite similar (both 0.14 ± 0.03, P = 0.91). The relative LV values distinguished between PAC (G) eyes and normal eyes better than the LV values (area under the receiver operator characteristic curve: 0.97 vs. 0.92, P = 0.032).

Conclusions: Our results suggest that relative dimensions of the eyeball's anterior portion in PAC (G) eyes might be within the normal range. And the value of LV relative to that of the AV (i.e., the relative LV) is more closely related to PAC (G) than is the absolute value of LV.

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Figures

Figure 1
Figure 1
Anterior-segment optical coherence tomography (AS-OCT) image illustrating measurement of anterior chamber depth (ACD), lens vault (LV), and anterior vault (AV) by Seoul Anterior-Segment Assessment Program (SAAP). Points SS and SS’ indicate the sclera spur positions. The relative LV (rLV) was calculated by dividing the LV by the AV.
Figure 2
Figure 2
Areas under the receiver-operating characteristic curves (AUROCs) of lens vault (LV) and relative LV (rLV) for distinguishing primary angle-closure (PAC) or primary angle-closure glaucoma PACG) subjects from normal subjects. The AUROCs significantly differed between the rLV and the LV (P = 0.032).
Figure 3
Figure 3
Examples of (A) PAC (G) and (B) normal-control eyes with similar lens vault (LV). The white horizontal lines connect the two scleral spurs (white points). (A) The LV is 1.03 mm, the anterior chamber depth (ACD) is 2.51 mm, and the anterior vault (AV) is 3.53 mm, in this eye with PAC (G). (B) The LV is 1.04 mm, the ACD is 3.19 mm, and the AV is 4.23 mm, in this eye with open-angle. The LV values are similar; however, due to the ACD difference, the relative LV values differ between (A) and (B) (0.29 in PAC[G] vs. 0.25 in normal-control eye).
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