Peptides come round: using SICLOPPS libraries for early stage drug discovery

Abstract

Cyclic peptides are an emerging class of molecular therapeutics that are increasingly viewed as ideal backbones for modulation of protein-protein interactions. A split-intein based method, termed SICLOPPS, enables the rapid generation of genetically encoded cyclic peptide libraries of around a hundred million members. Here we review recent approaches using SICLOPPS for the discovery of bioactive compounds.

Keywords: SICLOPPS; cyclic peptides; drug discovery; high throughput screening; medicinal chemistry; protein-protein interactions.