Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2014 Sep 1;120(17):2728-34.
doi: 10.1002/cncr.28684. Epub 2014 Jul 14.

Increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States

Franklin L Chien  1 , Stephen M Schwartz, Rebecca H Johnson
Affiliations
Comparative Study

Increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States

Franklin L Chien et al. Cancer. .

Abstract

Background: Although rising incidence rates of testicular germ cell tumors have been well documented in white men, relatively little is known about rates in men of Hispanic origin. In the current study, the authors compared germ cell tumor trends between men of Hispanic and non-Hispanic origin as a function of age at diagnosis.

Methods: Trends in testicular germ cell tumor incidence among white men were analyzed according to Hispanic ethnicity in 2 data sets of the National Cancer Institute's Surveillance, Epidemiology, and End Results Program, spanning from 1992 to 2010 and from 2000 to 2010 and sampling 15% and 28% of the United States population, respectively. Rates were age-adjusted to the year 2000 US standard population.

Results: Between 1992 and 2010, the annual incidence of testicular germ cell tumors among Hispanic whites ages 15 to 39 years increased 58%, from 7.18 cases per 100,000 in 1992 to 11.34 cases per 100,000 by 2010 (P<1 × 10(-9) ). Their incidence rates increased in metropolitan areas for both seminoma and nonseminoma subtypes and for all stages at diagnosis. During the same 19-year interval, incidence among non-Hispanic white young adults increased 7%, from 12.41 to 13.22 per 100,000. During the 2000 to 2010 interval, no significant trends were observed in incidence among non-Hispanic whites.

Conclusions: There has been a recent substantial increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States. Similar trends were not observed in non-Hispanic whites.

Keywords: Hispanic; adolescent; incidence; testicular cancer; young adult.

PubMed Disclaimer

Conflict of interest statement

Disclosure of Potential Conflicts of Interest:

No potential conflicts of interest were disclosed

Figures

Figure 1
Figure 1
Age-adjusted testicular germ cell tumor incidence rates among white adolescents and young adults of Hispanic and non-Hispanic origin, SEER13 and SEER18 databases, 1992–2010.
Figure 2
Figure 2
Annual percent change in age-adjusted TGCT incidence for Hispanic (top panel) and non-Hispanic (bottom panel) white men by 5-year age group. Vertical lines depict 95% confidence intervals, SEER13 database, 1992–2010.
See this image and copyright information in PMC

References

    1. Ries LAG, Young JL, Keel GE, Eisner MP, Lin YD, Horner M-J. SEER survival monograph: Cancer survival among adults: US SEER program, 1988–2001. patient and tumor characteristics. 2007
    1. Howlader N, Noone AM, Krapcho M, Neyman N, Aminou R, Altekruse SF, Kosary CL, Ruhl J, Tatalovich Z, Cho H, Mariotto A, Eisner MP, Lewis DR, Chen HS, Feuer EJ, Cronin KA, editors. SEER cancer statistics review, 1975–2009 (vintage 2009 populations) http://Seer.cancer.gov/statfacts/html/testis.html.
    1. Rosen A, Jayram G, Drazer M, Eggener SE. Global trends in testicular cancer incidence and mortality. Eur Urol. 2011 Aug;60(2):374–379. - PubMed
    1. Chia VM, Quraishi SM, Devesa SS, Purdue MP, Cook MB, McGlynn KA. International trends in the incidence of testicular cancer, 1973–2002. Cancer Epidemiol Biomarkers Prev. 2010 May;19(5):1151–1159. - PMC - PubMed
    1. Shah MN, Devesa SS, Zhu K, McGlynn KA. Trends in testicular germ cell tumours by ethnic group in the united states. Int J Androl. 2007 Aug;30(4):206. 13; discussion 213–4. - PubMed

Publication types