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. 2014 Jul;10(3):272-5.
doi: 10.3988/jcn.2014.10.3.272. Epub 2014 Jul 3.

Opsoclonus-myoclonus syndrome associated with mumps virus infection

Bong-Hui Kang  1 , Jae-Il Kim  2
Affiliations

Opsoclonus-myoclonus syndrome associated with mumps virus infection

Bong-Hui Kang et al. J Clin Neurol. 2014 Jul.

Abstract

Background: Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder that is characterized by involuntary eye movements and myoclonus. OMS exhibits various etiologies, including paraneoplastic, parainfectious, toxic-metabolic, and idiopathic causes. The exact immunopathogenesis and pathophysiology of OMS are uncertain.

Case report: We report the case of a 19-year-old male who developed opsoclonus and myoclonus several days after a flu-like illness. Serological tests revealed acute mumps infection. The findings of cerebrospinal fluid examinations and brain magnetic resonance imaging were normal. During the early phase of the illness, he suffered from opsoclonus and myoclonus that was so severe as to cause acute renal failure due to rhabdomyolysis. After therapies including intravenous immunoglobulin, the patient gradually improved and had fully recovered 2 months later.

Conclusions: This is the first report of OMS associated with mumps infection in Korea. Mumps infection should be considered in patients with OMS.

Keywords: mumps virus; myoclonus; opsoclonus.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
There is no abnormality on the brain MRIs.
See this image and copyright information in PMC

References

    1. Wong A. An update on opsoclonus. Curr Opin Neurol. 2007;20:25–31. - PubMed
    1. Klaas JP, Ahlskog JE, Pittock SJ, Matsumoto JY, Aksamit AJ, Bartleson JD, et al. Adult-onset opsoclonus-myoclonus syndrome. Arch Neurol. 2012;69:1598–1607. - PubMed
    1. Bataller L, Graus F, Saiz A, Vilchez JJ Spanish Opsoclonus-Myoclonus Study Group. Clinical outcome in adult onset idiopathic or paraneoplastic opsoclonus-myoclonus. Brain. 2001;124:437–443. - PubMed
    1. Ramat S, Leigh RJ, Zee DS, Optican LM. Ocular oscillations generated by coupling of brainstem excitatory and inhibitory saccadic burst neurons. Exp Brain Res. 2005;160:89–106. - PubMed
    1. Wong AM, Musallam S, Tomlinson RD, Shannon P, Sharpe JA. Opsoclonus in three dimensions: oculographic, neuropathologic and modelling correlates. J Neurol Sci. 2001;189:71–81. - PubMed

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