Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014:2014:919323.
doi: 10.1155/2014/919323. Epub 2014 Jun 22.

Prognostic factors and survival in patients treated surgically for recurrent metastatic uterine leiomyosarcoma

Han L T Hoang  1 , Kelsey Ensor  2 , Gerald Rosen  3 , H Leon Pachter  1 , Joseph S Raccuia  1
Affiliations

Prognostic factors and survival in patients treated surgically for recurrent metastatic uterine leiomyosarcoma

Han L T Hoang et al. Int J Surg Oncol. 2014.

Abstract

Background: Uterine leiomyosarcoma (LMS) is a rare diagnosis, which is seldom cured when it recurs with metastatic disease. We evaluated patients who present with first time recurrence treated surgically to determine prognostic factors associated with long-term survival.

Methods: Over a 16-year period, 41 patients were operated on for recurrent uterine sarcoma. Data examined included patient age, date of initial diagnosis, tumor histology, grade at the initial diagnosis, cytopathology changes in tumor activity from the initial diagnosis, residual tumor after all operations, use of adjuvant therapy, dates and sites of all recurrences, and disease status at last followup.

Results: 24 patients were operated for first recurrence of metastatic uterine LMS. Complete tumor resection with histologic negative margins was achieved in 16 (67%) patients. Overall survival was significantly affected by the FIGO stage at the time of the initial diagnosis, the ability to obtain complete tumor resection at the time of surgery for first time recurrent disease, single tumor recurrence, and recurrence greater than 12 months from the time of the initial diagnosis. Median disease-free survival was 14 months and overall survival was 27 months.

Conclusion: Our findings suggest that stage 1 at the time of initial diagnosis, recurrence greater than 12 months, isolated tumor recurrence, and the ability to remove ability to perform complete tumor resection at the time of the first recurrence can afford improved survival in selected patientsat the time of the first recurrence can afford improved survival in selected patients.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Figure 2
Figure 2
Figure 3
Figure 3
Figure 4
Figure 4
Figure 5
Figure 5
See this image and copyright information in PMC

References

    1. Leibsohn S, D’Ablaing G, Mishell DR, Jr., Schlaerth JB. Leiomyosarcoma in a series of hysterectomies performed for presumed uterine leiomyomas. American Journal of Obstetrics and Gynecology. 1990;162(4):968–976. - PubMed
    1. Kho K, Nezhat C. Evaluating the risks of electric uterine morecellation. The Journal of the American Medical Association. 2014;311:905–906. - PubMed
    1. Harlow BL, Weiss NS, Lofton S. The epidemiology of sarcomas of the uterus. Journal of the National Cancer Institute. 1986;76(3):399–402. - PubMed
    1. Gadducci A, Landoni F, Sartori E, et al. Uterine leiomyosarcoma: analysis of treatment failures and survival. Gynecologic Oncology. 1996;62(1):25–32. - PubMed
    1. Salazar OM, Bonfiglio TA, Patten SF, et al. Uterine sarcomas: natural history, treatment and prognosis. Cancer. 1978;42(3):1152–1160. - PubMed

Publication types

MeSH terms

LinkOut - more resources