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. 2014 Jun;41(2):86-91.
doi: 10.5653/cerm.2014.41.2.86. Epub 2014 Jun 30.

Serum luteinizing hormone level and luteinizing hormone/follicle-stimulating hormone ratio but not serum anti-Müllerian hormone level is related to ovarian volume in Korean women with polycystic ovary syndrome

Sungwook Chun  1
Affiliations

Serum luteinizing hormone level and luteinizing hormone/follicle-stimulating hormone ratio but not serum anti-Müllerian hormone level is related to ovarian volume in Korean women with polycystic ovary syndrome

Sungwook Chun. Clin Exp Reprod Med. 2014 Jun.

Abstract

Objective: The aim of the present study was to investigate the relationship between ovarian follicle count and volume on ultrasonography and serum hormone levels including the levels of the anti-Müllerian hormone (AMH) and gonadotropin in women with the polycystic ovary syndrome (PCOS).

Methods: A total of 118 Korean women aged 18-35 years who were newly diagnosed with PCOS at a university hospital were included in this study. Serum LH, FSH, and AMH levels were measured in the early follicular phase, and the total antral follicle count (TFC) and the total ovarian volume (TOV) were assessed by ultrasonography. The correlations between serum hormonal parameters and ultrasonography characteristics in women with PCOS were evaluated using Pearson's correlation coefficients and a linear regression analysis.

Results: Serum AMH levels were significantly correlated with serum LH levels and LH/FSH ratios, and TFC and TOV were significantly correlated with each other on ultrasonography. Serum AMH and LH levels and the LH/FSH ratio were significantly correlated with TFC. Statistically significant correlations between TOV and the LH level (r=0.208, p=0.024) and the LH/FSH ratio (r=0.237, p=0.010) were observed. However, the serum AMH level was not significantly correlated with the ovarian volume, and this result did not change after adjusting for age and body mass index.

Conclusion: Serum AMH is not related to the ovarian volume in women with PCOS. My results suggest that serum LH level and the LH/FSH ratio may be more useful than the serum AMH level for representing the status of the ovarian volume in women with PCOS.

Keywords: Anti-Müllerian hormone; Luteinizing hormone; Luteinizing hormone/follicle-stimulating hormone ratio; Ovarian volume; Polycystic ovary syndrome.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1
Correlations between (A) serum anti-Müllerian hormone levels and luteinizing hormone/follicle-stimulating hormone ratios; and (B) total antral follicle count and total ovarian volume. AMH, anti-Müllerian hormone; TFC, total antral follicle count; TOV, total ovarian volume.
Figure 2
Figure 2
Correlations between (A) serum anti-Müllerian hormone levels and total antral follicle count; and (B) serum luteinizing hormone/follicle-stimulating hormone ratios and total ovarian volume. r, Pearson's correlation coefficient; TFC, total antral follicle count; TOV, total ovarian volume.
See this image and copyright information in PMC

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