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. 2014:2014:474016.
doi: 10.1155/2014/474016. Epub 2014 Jun 19.

Denture-related stomatitis is associated with endothelial dysfunction

Joanna Maciąg  1 , Grzegorz Osmenda  2 , Daniel Nowakowski  1 , Grzegorz Wilk  2 , Anna Maciąg  3 , Tomasz Mikołajczyk  2 , Ryszard Nosalski  2 , Agnieszka Sagan  4 , Magdalena Filip  2 , Mirosław Dróżdż  2 , Jolanta Loster  5 , Tomasz J Guzik  4 , Marta Cześnikiewicz-Guzik  6
Affiliations

Denture-related stomatitis is associated with endothelial dysfunction

Joanna Maciąg et al. Biomed Res Int. 2014.

Abstract

Oral inflammation, such as periodontitis, can lead to endothelial dysfunction, accelerated atherosclerosis, and vascular dysfunction. The relationship between vascular dysfunction and other common forms of oral infections such as denture-related stomatitis (DRS) is unknown. Similar risk factors predispose to both conditions including smoking, diabetes, age, and obesity. Accordingly, we aimed to investigate endothelial function and major vascular disease risk factors in 44 consecutive patients with dentures with clinical and microbiological features of DRS (n = 20) and without DRS (n = 24). While there was a tendency for higher occurrence of diabetes and smoking, groups did not differ significantly in respect to major vascular disease risk factors. Groups did not differ in main ambulatory blood pressure, total cholesterol, or even CRP. Importantly, flow mediated dilatation (FMD) was significantly lower in DRS than in non-DRS subjects, while nitroglycerin induced vasorelaxation (NMD) or intima-media thickness (IMT) was similar. Interestingly, while triglyceride levels were normal in both groups, they were higher in DRS subjects, although they did not correlate with either FMD or NMD.

Conclusions: Denture related stomatitis is associated with endothelial dysfunction in elderly patients with dentures. This is in part related to the fact that diabetes and smoking increase risk of both DRS and cardiovascular disease.

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Figures

Figure 1
Figure 1
Ambulatory blood pressure parameters in control and DRS patients. Blood pressure parameters were assessed by 24 h measurement with ambulatory blood pressure monitoring system. Results are presented as mean (SD); n control group = 23, n DRS group = 20.
Figure 2
Figure 2
Vascular dysfunction in control and DRS. Vascular endothelium-dependent flow-mediated dilatation (FMD) and endothelium-independent nitroglycerin-mediated dilatation (NMD) parameters were assessed by ultrasonography. Results presented as median (Q1; Q2); ∗P < 0,005; n control group = 24, n DRS group = 20.
Figure 3
Figure 3
IMT measurements in DRS and control group. (a) Mean common carotid artery intima-media thickness. Results are presented as mean (SD); (b) maximal common carotid artery intima-media thickness. Results presented as median (Q1; Q2). (a) and (b): n control group = 24, n DRS group = 20.
Figure 4
Figure 4
Plasma lipid profile and C-reactive protein levels in control and DRS patients. (a) Comparison of lipid profiles. Results are presented as median (Q1; Q2); ∗P < 0,05; (b) comparison of plasma CRP concentrations. Results are presented as median (Q1; Q2). (a) and (b): n control group = 24, n DRS group = 18.
Figure 5
Figure 5
Spearman correlation between parameters of vascular function parameters and triglycerides levels. (a) Spearman correlation between FMD and triglycerides levels: R Spearman = −0,13, P = 0,42; (b) Spearman correlation between NMD and triglycerides levels: R Spearman = −0, 025, P = 0,87; (a) and (b): n = 42.
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