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Comment
. 2014 Oct;15(10):1299-300.
doi: 10.4161/cbt.29928. Epub 2014 Jul 21.

Ipilimumab: a potential immunologic agent in the treatment of metastatic castration-resistant prostate cancer

Adam Kittai  1 , Mariam Meshikhes  2 , Jeanny B Aragon-Ching  3
Affiliations
Comment

Ipilimumab: a potential immunologic agent in the treatment of metastatic castration-resistant prostate cancer

Adam Kittai et al. Cancer Biol Ther. 2014 Oct.

Abstract

Immunotherapy has garnered an important place in the therapeutic landscape of treatment in prostate cancer since approval of sipuleucel-T. Ipilimumab is a checkpoint inhibitor that is currently approved for the treatment of advanced melanoma. In the June issue of Lancet Oncology, Kwon and colleagues report the phase III trial using ipilimumab in a post-docetaxel metastatic castration-resistant prostate cancer population. While the primary endpoint of overall survival was not met, several lessons are learned from the analysis of this trial. Perhaps better refinement of a more favorable group of patients who may potentially benefit from an immunologic treatment should be advocated.

Keywords: ipilimumab; prostate cancer.

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Comment on

  • Sipuleucel-T immunotherapy for castration-resistant prostate cancer.
    Kantoff PW, Higano CS, Shore ND, Berger ER, Small EJ, Penson DF, Redfern CH, Ferrari AC, Dreicer R, Sims RB, Xu Y, Frohlich MW, Schellhammer PF; IMPACT Study Investigators. Kantoff PW, et al. N Engl J Med. 2010 Jul 29;363(5):411-22. doi: 10.1056/NEJMoa1001294. N Engl J Med. 2010. PMID: 20818862 Clinical Trial.

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