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Review
. 2014:2014:950472.
doi: 10.1155/2014/950472. Epub 2014 Jun 23.

The regulatory role of activating transcription factor 2 in inflammation

Tao Yu  1 , Yong Jun Li  2 , Ai Hong Bian  3 , Hui Bin Zuo  2 , Ti Wen Zhu  2 , Sheng Xiang Ji  2 , Fanming Kong  2 , De Qing Yin  2 , Chuan Bao Wang  2 , Zi Fu Wang  2 , Hong Qun Wang  2 , Yanyan Yang  4 , Byong Chul Yoo  5 , Jae Youl Cho  4
Affiliations
Review

The regulatory role of activating transcription factor 2 in inflammation

Tao Yu et al. Mediators Inflamm. 2014.

Abstract

Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA-binding proteins and is widely distributed in tissues including the liver, lung, spleen, and kidney. Like c-Jun and c-Fos, ATF2 responds to stress-related stimuli and may thereby influence cell proliferation, inflammation, apoptosis, oncogenesis, neurological development and function, and skeletal remodeling. Recent studies clarify the regulatory role of ATF2 in inflammation and describe potential inhibitors of this protein. In this paper, we summarize the properties and functions of ATF2 and explore potential applications of ATF2 inhibitors as tools for research and for the development of immunosuppressive and anti-inflammatory drugs.

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Figures

Figure 1
Figure 1
Characteristics of ATF proteins. ATF: activating transcription factor; LZ: leucine zipper; NBD: nucleotide-binding domain.
Figure 2
Figure 2
ATF-2-regulated signaling pathways in inflammatory response.
See this image and copyright information in PMC

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