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. 2014 Apr 25:3:e28222.
doi: 10.4161/onci.28222. eCollection 2014.

The heat shock protein-CD91 pathway mediates tumor immunosurveillance

Yu Jerry Zhou  1 , Robert Julian Binder  1
Affiliations

The heat shock protein-CD91 pathway mediates tumor immunosurveillance

Yu Jerry Zhou et al. Oncoimmunology. .

Abstract

Tumor immunosurveillance can be readily observed in mice and humans. Here, we examine how T-cell responses are primed during tumorigenesis, a condition in which immunostimulatory antigens are extraordinarily scarce. We recently demonstrated that the HSP-CD91 pathway is indispensable for antigen cross-presentation, and thus immunosurveillance, in cancer.

Keywords: CD91; HSP; T cells; cross-presentation; tumor.

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Figures

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Figure 1. A mechanism for antigen transfer, cross-presentation, and priming of T-cell responses to cancer antigens. Extracellular HSP-peptide complexes engage CD91 on the surface of APCs. CD91 allows for cross-presentation of the chaperoned antigens and promotes downstream signaling cascades culminating in co-stimulation of T cells. APC, antigen-presenting cell; HSP, heat-shock protein
See this image and copyright information in PMC

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