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. 2014 Aug 13;136(32):11256-9.
doi: 10.1021/ja505794u. Epub 2014 Aug 4.

Regio- and chemoselective intermolecular hydroamination of allyl imines for the synthesis of 1,2-diamines

Andrew R Ickes  1 , Seth C Ensign, Anil K Gupta, Kami L Hull
Affiliations

Regio- and chemoselective intermolecular hydroamination of allyl imines for the synthesis of 1,2-diamines

Andrew R Ickes et al. J Am Chem Soc. .

Abstract

The synthesis of 1,2-diamines via a Rh-catalyzed intermolecular hydroamination of N-allyl imines with cyclic amines is presented. Coordinating groups proximal to the olefin bind to the catalyst and promote the transformation. The reaction affords 1,2-diamines in very good yields and is functional-group-tolerant and highly diastereoselective.

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