TYROBP in Alzheimer's disease

Abstract

Recently, studies have provided convincing data that TYRO protein tyrosine kinase-binding protein (TYROBP), a key regulator in immune systems, is significantly upregulated in the brain of patients with Alzheimer's disease (AD). TYROBP acts as a signaling adaptor protein for numerous cell surface receptors, playing important roles in signal transduction in dendritic cells, osteoclasts, macrophages, and microglia. Although several TYROBP-related cell surface receptors including triggering receptor expressed on myeloid 2 (TREM2), signal regulatory protein β1 (SIRPβ1), and complement receptor 3 (CR3) were found to participate in the pathogenesis of AD, the role of TYROBP in AD still remains elusive. Emerging piece of evidence has demonstrated that TYROBP could enhance phagocytic activity of microglia, which is responsible for the clearance of amyloid-β (Aβ) peptides and apoptotic neurons. TYROBP also participates in suppression of inflammatory responses by repression of microglia-mediated cytokine production and secretion. In this article, we introduce the structure, localization, and function of TYROBP. Meanwhile, we review recent articles concerning the association of TYROBP and its related receptors with AD pathogenesis and speculate the possible roles of TYROBP in this disease. Based on the potential protective actions of TYROBP in AD pathogenesis, targeting TYROBP might provide new opportunities for AD treatment.