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. 2014 Jun;10(8):1343-51.
doi: 10.2217/fon.14.76.

Anti-Müllerian hormone as an ovarian reserve marker in young cancer women who undergo ovarian tissue cryopreservation

Raffaella Fabbri  1 , Maria Macciocca, Cristina Melotti, Gianandrea Pasquinelli, Rossella Vicenti, Maria Letizia Bacchi Reggiani, Daniela Terribile, Stefano Venturoli
Affiliations

Anti-Müllerian hormone as an ovarian reserve marker in young cancer women who undergo ovarian tissue cryopreservation

Raffaella Fabbri et al. Future Oncol. 2014 Jun.

Abstract

Aim: To evaluate if anti-Müllerian hormone (AMH) is a reliable marker of ovarian reserve in young women undergoing ovarian tissue cryopreservation.

Patients & methods: Relationships of serum AMH levels with primordial follicle density, age and reproductive hormones were investigated using the Pearson or Spearman correlation coefficient in 86 women with cancer (12-38 years) undergoing ovarian tissue cryopreservation. AMH variations through the menstrual cycle were assessed by the Kruskal-Wallis test. p < 0.05 was accepted as significant.

Results: AMH positively correlated with primordial follicle density (p = 0.03), showed great interindividual variability at all ages and negatively correlated with estradiol (p = 0.007) in the early follicular phase. AMH did not vary across the menstrual cycle (p = 0.415).

Conclusion: AMH appears a valid ovarian reserve marker in young cancer women.

Keywords: anti-Müllerian hormone; menstrual cycle; ovarian reserve; ovarian tissue cryopreservation; primordial follicles.

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