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. 2014 Oct;80(2):154-8.
doi: 10.1016/j.diagmicrobio.2014.06.010. Epub 2014 Jun 23.

Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system

Chulsoo Ahn  1 , Alveena Syed  1 , Fupin Hu  2 , Jessica A O'Hara  1 , Jesabel I Rivera  1 , Yohei Doi  3
Affiliations

Microbiological features of KPC-producing Enterobacter isolates identified in a U.S. hospital system

Chulsoo Ahn et al. Diagn Microbiol Infect Dis. 2014 Oct.

Abstract

Microbiological data regarding Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacter spp. are scarce. In this study, 11 unique KPC-producing Enterobacter isolates were identified among 44 ertapenem-nonsusceptible Enterobacter isolates collected between 2009 and 2013 at a hospital system in Western Pennsylvania. All cases were healthcare-associated and occurred in medically complex patients. While pulsed-field gel electrophoresis showed diverse restriction patterns overall, multilocus sequence typing identified Enterobacter cloacae isolates with sequence types 93 and 171 from 2 hospitals each. The levels of carbapenem minimum inhibitory concentrations were highly variable. All isolates remained susceptible to colistin and tigecycline, and the majority, to amikacin and doxycycline. A blaKPC-carrying IncN plasmid conferring trimethoprim-sulfamethoxazole resistance was identified in 3 of the isolates. Spread of blaKPC in Enterobacter spp. appears to be due to a combination of plasmid-mediated and clonal processes.

Keywords: Enterobacter aerogenes; Enterobacter cloacae; Klebsiella pneumoniae carbapenemease.

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Figures

Figure
Figure
PFGE profiles and STs of the KPC-producing Enterobacter isolates.
See this image and copyright information in PMC

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