Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Aug;15(8):525-35.
doi: 10.1038/nrm3840.

Small RNAs break out: the molecular cell biology of mobile small RNAs

Peter Sarkies  1 , Eric A Miska  1
Affiliations
Review

Small RNAs break out: the molecular cell biology of mobile small RNAs

Peter Sarkies et al. Nat Rev Mol Cell Biol. 2014 Aug.

Abstract

Small RNAs that function in a non-cell autonomous manner are becoming increasingly recognized as regulatory molecules with the potential to transmit information between cells, organisms and species. In plants and nematodes, small RNA mobility can be genetically dissected to provide information about the nature of the mobile RNA species, their distribution in the organism and inside cells, as well as the cellular machinery required for mobility, including channel proteins and cellular trafficking factors. Mobile RNAs function in antiviral defence, cell signalling and gene expression regulation, and might also mediate transgenerational epigenetic inheritance.

PubMed Disclaimer

References

    1. Elife. 2013 Oct 08;2:e00994 - PubMed
    1. Mol Cell. 2010 Mar 12;37(5):679-89 - PubMed
    1. Genes Dev. 2001 Oct 15;15(20):2654-9 - PubMed
    1. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10565-70 - PubMed
    1. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14520-5 - PubMed

Publication types

Substances