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Review
. 2014 Jul 9:6:14.
doi: 10.1186/2045-824X-6-14. eCollection 2014.

Flow-regulated lymphatic vasculature development and signaling

Yingdi Wang  1 , Michael Simons  2
Affiliations
Review

Flow-regulated lymphatic vasculature development and signaling

Yingdi Wang et al. Vasc Cell. .

Abstract

The role of blood flow in regulating signaling pathways and gene expression in the blood vasculature is well known. Recent studies have identified equally important roles of flow-mediated signaling in the lymphatic circulation including control of lymphatic vascular growth, remodeling, regeneration and maintenance of the lymphatic fate. In this review, we summarize these advances focusing on the role of fluid dynamics in control of lymphatic vasculature formation.

Keywords: Flow; Lymphatic endothelial cells; Lymphatic vascular development; Shear stress; Signaling.

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Figures

Figure 1
Figure 1
Fluid flow in lymphatic vasculature development in mice. (A) Flow triggers lymphatic valve development. At approximately embryonic day (E)16.0, lymph flow induces Cx37 expression and activates calcineurin/NFATc1 signaling in lymphatic-valve-forming cells initiating luminal valve development. (B) Fluid flow plays a role in lymphatic fate maintenance. In mice, loss of Slp-76 results in shunt formation between blood and lymphatic vessels in mesentery and, therefore mixing of blood and lymphatic circulation. The presence of blood flow in lymphatic vessels in Slp-76 null mice causes the change of lymphatic fate to a venous identity.
See this image and copyright information in PMC

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